Several medicine classes can make you feel cold. Beta blockers, ADHD stimulants, triptans and ergot drugs can narrow blood flow to the fingers and toes; oxaliplatin causes nerve symptoms triggered by cold; and antipsychotics can occasionally lower core body temperature. A 2016 review identified 12 drug classes linked to Raynaud's phenomenon. Never stop a medicine on your own; talk to your prescriber first.

Hypothyroidism makes you feel cold because low thyroid hormone slows the body's metabolism, so it produces less heat at rest and less extra heat when you are chilled. In a Swiss study, restoring normal thyroid levels raised the body's heat response to mild cold by about 102%. Most people warm up with proper treatment, but persistent cold deserves a talk with your clinician.

Yes, ADHD stimulants can cause cold hands. US labels for amphetamine (Adderall XR) and methylphenidate (Concerta) warn that these medicines are associated with peripheral vasculopathy, including Raynaud's phenomenon: fingers or toes that feel numb, cool or painful and turn pale, blue, then red. Symptoms are usually mild and intermittent. Tell the prescriber, and do not change the dose on your own.

Yes. Cold hands and feet are a recognized side effect of beta blockers. The NHS lists them among common side effects, and US labels for metoprolol and propranolol list cold extremities or arterial insufficiency of the Raynaud type. Beta blockers lower the heart's output and can block signals that widen small blood vessels. Never stop one suddenly; talk to your prescriber.

Feeling cold is not a listed side effect of Zepbound or Mounjaro. Neither US prescribing information lists chills, feeling cold or cold intolerance. The likely reasons are indirect: tirzepatide decreases calorie intake, and weight lost is mostly fat, which insulates. Listed effects such as fatigue, dizziness and low blood pressure can also feel like a chill. Persistent cold deserves a talk with your clinician.

Losing weight can make you feel colder because you have less body fat to insulate you and because eating less turns down heat production. In a six-month JAMA trial, people on calorie restriction had lower core body temperature and burned about 135 fewer calories a day while sedentary. Cold that is extreme, long-lasting or comes with unplanned weight loss deserves a clinician's check.